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Structure paper

TitleThe structures of salt-inducible kinase 3 in complex with inhibitors reveal determinants for binding and selectivity.
Journal, issue, pagesJ. Biol. Chem., Vol. 300, Page 107201-107201, Year 2024
Publish dateNov 14, 2023 (structure data deposition date)
AuthorsOster, L. / Castaldo, M. / de Vries, E. / Edfeldt, F. / Pemberton, N. / Gordon, E. / Cederblad, L. / Kack, H.
External linksJ. Biol. Chem. / PubMed:38508313
MethodsX-ray diffraction
Resolution1.9 - 2.838 Å
Structure data

PDB-8r4o:
Salt inducible kinase 3 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.725 Å

PDB-8r4q:
Salt inducible kinase 3 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.838 Å

PDB-8r4u:
Structure of salt-inducible kinase 3 with inhibitors
Method: X-RAY DIFFRACTION / Resolution: 2.416 Å

PDB-8r4v:
Structure of Salt-inducible kinase 3 in complex with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals


ChemComp, No image

ChemComp-XVI:
Unknown entry

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-DB8:
4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile / inhibitor, medication*YM


ChemComp, No image

ChemComp-XW3:
Unknown entry


ChemComp, No image

ChemComp-XWA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsLIGASE / Kinase Inhibitor complex AMPK-like salt-induced kinase / kinase / inhibitor complex / drug design / ampk-like kinase / UBA / ampk-like

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