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Structure paper

TitleExperimental Structures of Antibody/MHC-I Complexes Reveal Details of Epitopes Overlooked by Computational Prediction.
Journal, issue, pagesJ Immunol., Vol. 212, Page 1366-1380, Year 2024
Publish dateAug 6, 2023 (structure data deposition date)
AuthorsBoyd, L.F. / Jiang, J. / Ahmad, J. / Natarajan, K. / Margulies, D.H.
External linksJ Immunol. / PubMed:38456672
MethodsX-ray diffraction
Resolution2.6 - 2.9 Å
Structure data

PDB-8tq7:
Crystal structure of Fab.34.2.12 in complex with MHC-I (H2-Dd)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-8tq8:
Crystal structure of Fab.34.5.8 in complex with MHC-I (H2-Dd)
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-8tq9:
Crystal structure of Fab.S19.8 in complex with MHC-I (H2-Dd)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8tqa:
Crystal structure of Fab.28.14.8 in complex with MHC-I (H2-Db)
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • mus musculus (house mouse)
  • hiv-1 m:b_hxb2r (virus)
  • human immunodeficiency virus 1
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / histocompatibility complex class I / MHC-I / immune response / immune system Fab / antibody / anti-MHC antibody / cancer tumor

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