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TitleStructural insights into the molecular mechanism of high-level ceftazidime-avibactam resistance conferred by CMY-185.
Journal, issue, pagesMbio, Vol. 15, Page e0287423-e0287423, Year 2024
Publish dateMay 8, 2023 (structure data deposition date)
AuthorsKawai, A. / Shropshire, W.C. / Suzuki, M. / Borjan, J. / Aitken, S.L. / Bachman, W.C. / McElheny, C.L. / Bhatti, M.M. / Shields, R.K. / Shelburne, S.A. / Doi, Y.
External linksMbio / PubMed:38179965
MethodsX-ray diffraction
Resolution1.35 - 2.4 Å
Structure data

PDB-8jb7:
Crystal structure of CMY-185
Method: X-RAY DIFFRACTION / Resolution: 1.35 Å

PDB-8jb8:
Crystal structure of CMY-185 complex with ceftazidime
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CAZ:
ACYLATED CEFTAZIDIME

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE / Beta-lactamase / CMY-2-like

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