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Structure paper

TitleDiscovery of FERM domain protein-protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer's disease.
Journal, issue, pagesJ. Biol. Chem., Vol. 299, Page 105382-105382, Year 2023
Publish dateJan 14, 2020 (structure data deposition date)
AuthorsDu, Y. / Bradshaw, W.J. / Leisner, T.M. / Annor-Gyamfi, J.K. / Qian, K. / Bashore, F.M. / Sikdar, A. / Nwogbo, F.O. / Ivanov, A.A. / Frye, S.V. ...Du, Y. / Bradshaw, W.J. / Leisner, T.M. / Annor-Gyamfi, J.K. / Qian, K. / Bashore, F.M. / Sikdar, A. / Nwogbo, F.O. / Ivanov, A.A. / Frye, S.V. / Gileadi, O. / Brennan, P.E. / Levey, A.I. / Axtman, A.D. / Pearce, K.H. / Fu, H. / Katis, V.L.
External linksJ. Biol. Chem. / PubMed:37866628
MethodsX-ray diffraction
Resolution1.52 - 2.536 Å
Structure data

PDB-6txq:
The high resolution structure of the FERM domain and helical linker of human moesin
Method: X-RAY DIFFRACTION / Resolution: 1.73 Å

PDB-6txs:
The structure of the FERM domain and helical linker of human moesin bound to a CD44 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-8cir:
The FERM domain of human moesin with a bound peptide identified by phage display
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-8cis:
The FERM domain of human moesin with two bound peptides identified by phage display
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

PDB-8cit:
The FERM domain of human moesin mutant L281R
Method: X-RAY DIFFRACTION / Resolution: 2.536 Å

PDB-8ciu:
The FERM domain of human moesin mutant H288A
Method: X-RAY DIFFRACTION / Resolution: 2.393 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

ChemComp-BR:
BROMIDE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-B3P:
2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsPROTEIN BINDING / PIP / FERM domain / Alzheimer's disease / CD44

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