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TitleA riboside hydrolase that salvages both nucleobases and nicotinamide in the auxotrophic parasite Trichomonas vaginalis.
Journal, issue, pagesJ. Biol. Chem., Vol. 299, Page 105077-105077, Year 2023
Publish dateMar 22, 2023 (structure data deposition date)
AuthorsPatrone, M. / Galasyn, G.S. / Kerin, F. / Nyitray, M.M. / Parkin, D.W. / Stockman, B.J. / Degano, M.
External linksJ. Biol. Chem. / PubMed:37482279
MethodsX-ray diffraction
Resolution1.85 - 2.8 Å
Structure data

PDB-8oi7:
Trichomonas vaginalis riboside hydrolase
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-8oi9:
Trichomonas vaginalis riboside hydrolase in complex with 5-methyluridine
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-8oia:
Trichomonas vaginalis riboside hydrolase in complex with D-ribose
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-8oib:
Trichomonas vaginalis riboside hydrolase in complex with glycerol
Method: X-RAY DIFFRACTION / Resolution: 2.44 Å

PDB-8oic:
Trichomonas vaginalis riboside hydrolase (His-tagged)
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-MG:
Unknown entry

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

ChemComp-38T:
5-methyluridine

ChemComp-PIN:
PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-RIB:
alpha-D-ribofuranose

ChemComp-GOL:
GLYCEROL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-BCN:
BICINE / pH buffer*YM

Source
  • trichomonas vaginalis (eukaryote)
KeywordsHYDROLASE / NH-fold / nucleoside hydrolase / riboside hydrolase / nicotinamide riboside

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