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TitleInteractions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity.
Journal, issue, pagesFront Mol Biosci, Vol. 10, Page 1192621-1192621, Year 2023
Publish dateMar 7, 2023 (structure data deposition date)
AuthorsGenera, M. / Colcombet-Cazenave, B. / Croitoru, A. / Raynal, B. / Mechaly, A. / Caillet, J. / Haouz, A. / Wolff, N. / Caillet-Saguy, C.
External linksFront Mol Biosci / PubMed:37200868
MethodsX-ray diffraction
Resolution1.7 - 1.87 Å
Structure data

PDB-8cqy:
Crystal structure of the PTPN3 PDZ domain bound to the PBM TACE C-terminal peptide
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-8oep:
Crystal structure of the PTPN3 PDZ domain bound to the HPV18 E6 oncoprotein C-terminal peptide
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • human papillomavirus 18
KeywordsHYDROLASE / protein tyrosine phosphatase PTPN3 / PDZ domains / PDZ-binding motif

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