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Structure paper

TitleQuantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability.
Journal, issue, pagesDis Model Mech, Vol. 16, Year 2023
Publish dateOct 13, 2021 (structure data deposition date)
AuthorsScelsi, H.F. / Hill, K.R. / Barlow, B.M. / Martin, M.D. / Lieberman, R.L.
External linksDis Model Mech / PubMed:36579626
MethodsX-ray diffraction
Resolution1.24 - 1.78 Å
Structure data

PDB-7sib:
Myocilin OLF mutant K500R
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-7sij:
Myocilin OLF mutant E352K
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-7sjt:
Myocilin OLF mutant K398R
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-7sju:
Myocilin OLF mutant T293K
Method: X-RAY DIFFRACTION / Resolution: 1.391 Å

PDB-7sjv:
Myocilin OLF mutant T353I
Method: X-RAY DIFFRACTION / Resolution: 1.39 Å

PDB-7sjw:
Myocilin OLF mutant L303I
Method: X-RAY DIFFRACTION / Resolution: 1.38 Å

PDB-7skd:
Myocilin OLF mutant S331L
Method: X-RAY DIFFRACTION / Resolution: 1.712 Å

PDB-7ske:
Myocilin OLF mutant R296H
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

PDB-7skf:
Myocilin OLF mutant A445V
Method: X-RAY DIFFRACTION / Resolution: 1.282 Å

PDB-7skg:
Myocilin OLF mutant V329M
Method: X-RAY DIFFRACTION / Resolution: 1.33 Å

PDB-7t8d:
Myocilin OLF mutant V449I
Method: X-RAY DIFFRACTION / Resolution: 1.38 Å

Chemicals

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-CA:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER / Water

Source
  • homo sapiens (human)
KeywordsCELL ADHESION / olfactomedin / beta-propeller

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