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-Structure paper
タイトル | Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus. |
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ジャーナル・号・ページ | Mbio, Vol. 13, Page e0104922-e0104922, Year 2022 |
掲載日 | 2022年2月18日 (構造データの登録日) |
![]() | Hoy, M.J. / Park, E. / Lee, H. / Lim, W.Y. / Cole, D.C. / DeBouver, N.D. / Bobay, B.G. / Pierce, P.G. / Fox 3rd, D. / Ciofani, M. ...Hoy, M.J. / Park, E. / Lee, H. / Lim, W.Y. / Cole, D.C. / DeBouver, N.D. / Bobay, B.G. / Pierce, P.G. / Fox 3rd, D. / Ciofani, M. / Juvvadi, P.R. / Steinbach, W. / Hong, J. / Heitman, J. |
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手法 | X線回折 |
解像度 | 1.7 - 2.45 Å |
構造データ | ![]() PDB-7u0s: ![]() PDB-7u0t: ![]() PDB-7u0u: |
化合物 | ![]() ChemComp-KXX: ![]() ChemComp-SO4: ![]() ChemComp-PG4: ![]() ChemComp-P6G: ![]() ChemComp-ACT: ![]() ChemComp-1PE: ![]() ChemComp-HOH: ![]() ChemComp-CA: ![]() ChemComp-EDO: ![]() ChemComp-PO4: ![]() ChemComp-FK5: |
由来 |
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![]() | ANTIFUNGAL PROTEIN / SSGCID / PPIase / Rapamycin-binding protein / FKBP / Peptidyl-prolyl cis-trans isomerase / Structural Genomics / Seattle Structural Genomics Center for Infectious Disease / HYDROLASE/ISOMERASE / CnA / CnB / FKBP12 / peptidyl prolyl cis-trans isomerase / phosphatase / FK-520 / HYDROLASE-ISOMERASE complex / Anti-fungal / Calcineurin / FK-506 / Tacrolimus |