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TitlePerturbing dimer interactions and allosteric communication modulates the immunosuppressive activity of human galectin-7.
Journal, issue, pagesJ. Biol. Chem., Vol. 297, Page 101308-101308, Year 2021
Publish dateFeb 13, 2020 (structure data deposition date)
AuthorsPham, N.T.H. / Letourneau, M. / Fortier, M. / Begin, G. / Al-Abdul-Wahid, M.S. / Pucci, F. / Folch, B. / Rooman, M. / Chatenet, D. / St-Pierre, Y. ...Pham, N.T.H. / Letourneau, M. / Fortier, M. / Begin, G. / Al-Abdul-Wahid, M.S. / Pucci, F. / Folch, B. / Rooman, M. / Chatenet, D. / St-Pierre, Y. / Lague, P. / Calmettes, C. / Doucet, N.
External linksJ. Biol. Chem. / PubMed:34673030
MethodsX-ray diffraction
Resolution1.69 - 2.3 Å
Structure data

PDB-6vto:
Crystal structure of human Galectin-7 in complex with 4-O-beta-D-Galactopyranosyl-D-glucose
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

PDB-6vtp:
Crystal structure of G16C human Galectin-7 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6vtq:
Crystal structure of G16C human Galectin-7 mutant in complex with lactose
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-6vtr:
Crystal structure of G16S human Galectin-7 mutant
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6vts:
Crystal structure of G16S human Galectin-7 mutant in complex with lactose
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-LBL:
(2~{R},3~{R},4~{R},5~{R})-4-[(2~{S},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,3,5,

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN / Human Galectin-7 / lactose-furanose / G16C mutant / disulfide bond / lactose / G16S mutant

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