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Structure paper

TitlecGAS-like receptors sense RNA and control 3'2'-cGAMP signalling in Drosophila.
Journal, issue, pagesNature, Vol. 597, Page 109-113, Year 2021
Publish dateFeb 18, 2021 (structure data deposition date)
AuthorsSlavik, K.M. / Morehouse, B.R. / Ragucci, A.E. / Zhou, W. / Ai, X. / Chen, Y. / Li, L. / Wei, Z. / Bahre, H. / Konig, M. ...Slavik, K.M. / Morehouse, B.R. / Ragucci, A.E. / Zhou, W. / Ai, X. / Chen, Y. / Li, L. / Wei, Z. / Bahre, H. / Konig, M. / Seifert, R. / Lee, A.S.Y. / Cai, H. / Imler, J.L. / Kranzusch, P.J.
External linksNature / PubMed:34261127
MethodsX-ray diffraction
Resolution1.58 - 2.4 Å
Structure data

PDB-7lt1:
Structure of the cGAS-like receptor human MB21D2
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-7lt2:
Structure of a dsRNA-sensing cGAS-like receptor from the beetle Tribolium castaneum
Method: X-RAY DIFFRACTION / Resolution: 1.58 Å

PDB-7mwy:
Structure of the drosophila STING cyclic dinucleotide binding domain
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

PDB-7mwz:
Structure of drosophila STING in complex with 3'2'-cGAMP
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-4UR:
3'2'-cGAMP

Source
  • homo sapiens (human)
  • tribolium castaneum (red flour beetle)
  • drosophila eugracilis (fry)
KeywordsIMMUNE SYSTEM / cGAS-like receptor / cGLR / nucleotidyltransferase / STING / cyclic dinucleotide receptor

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