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TitleTSC1 binding to lysosomal PIPs is required for TSC complex translocation and mTORC1 regulation.
Journal, issue, pagesMol. Cell, Vol. 81, Page 2705-, Year 2021
Publish dateAug 10, 2020 (structure data deposition date)
AuthorsFitzian, K. / Bruckner, A. / Brohee, L. / Zech, R. / Antoni, C. / Kiontke, S. / Gasper, R. / Linard Matos, A.L. / Beel, S. / Wilhelm, S. ...Fitzian, K. / Bruckner, A. / Brohee, L. / Zech, R. / Antoni, C. / Kiontke, S. / Gasper, R. / Linard Matos, A.L. / Beel, S. / Wilhelm, S. / Gerke, V. / Ungermann, C. / Nellist, M. / Raunser, S. / Demetriades, C. / Oeckinghaus, A. / Kummel, D.
External linksMol. Cell / PubMed:33974911
MethodsX-ray diffraction
Resolution2.32 - 4.3 Å
Structure data

PDB-7a0m:
TSC1 N-terminal domain
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

PDB-7a0n:
Structure of TSC1 NTD and linker domain
Method: X-RAY DIFFRACTION / Resolution: 4.3 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • chaetomium thermophilum (fungus)
  • chaetomium thermophilum (strain dsm 1495 / cbs 144.50 / imi 039719) (fungus)
KeywordsSIGNALING PROTEIN / TSC / GAP / GTPase signaling / TSC1 / GTPase

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