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TitleHelicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase-A Putative Target for Drug Discovery against Gastrointestinal Tract Infections.
Journal, issue, pagesJ. Med. Chem., Vol. 64, Page 5710-5729, Year 2021
Publish dateOct 29, 2020 (structure data deposition date)
AuthorsKeough, D.T. / Wun, S.J. / Baszczynski, O. / Eng, W.S. / Spacek, P. / Panjikar, S. / Naesens, L. / Pohl, R. / Rejman, D. / Hockova, D. ...Keough, D.T. / Wun, S.J. / Baszczynski, O. / Eng, W.S. / Spacek, P. / Panjikar, S. / Naesens, L. / Pohl, R. / Rejman, D. / Hockova, D. / Ferrero, R.L. / Guddat, L.W.
External linksJ. Med. Chem. / PubMed:33891818
MethodsX-ray diffraction
Resolution1.47 - 1.97 Å
Structure data

PDB-7kl6:
Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-7kl7:
Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

Chemicals

ChemComp-WG7:
(3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl)phosphonic acid

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • helicobacter pylori (bacteria)
KeywordsTRANSFERASE / Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase Drug discovery Nucleoside phosphonates / Helicobacter pylori Xanthine-Guanine-Hypoxanthine Phosphoribosyltransferase Drug discovery Nucleoside phosphates

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