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TitlePhenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by beta-Hairpins Derived from A beta.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 142, Page 20708-20716, Year 2020
Publish dateAug 27, 2020 (structure data deposition date)
AuthorsHaerianardakani, S. / Kreutzer, A.G. / Salveson, P.J. / Samdin, T.D. / Guaglianone, G.E. / Nowick, J.S.
External linksJ. Am. Chem. Soc. / PubMed:33237748
MethodsX-ray diffraction
Resolution2 - 2.81 Å
Structure data

PDB-7jxn:
Beta hairpin derived from Abeta17-36 with an F20Cha mutation
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7jxo:
Triangular trimer of beta-hairpins derived from Abeta17-36 with an F20Cha mutation
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDE NOVO PROTEIN / amyloid / oligomer / Alzheimer's disease / beta-hairpin

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