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TitleCrystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.
Journal, issue, pagesJ. Mol. Biol., Vol. 432, Page 5499-5508, Year 2020
Publish dateMar 29, 2020 (structure data deposition date)
AuthorsLei, X. / Zhao, J. / Sagendorf, J.M. / Rajashekar, N. / Xu, J. / Dantas Machado, A.C. / Sen, C. / Rohs, R. / Feng, P. / Chen, L.
External linksJ. Mol. Biol. / PubMed:32681840
MethodsX-ray diffraction
Resolution2.1 - 2.9 Å
Structure data

PDB-6wc2:
Crystal Structure of a Ternary MEF2 Chimera/NKX2-5/myocardin enhancer DNA Complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-6wc5:
Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / Transcription Factor / DNA binding Protein / Cardiogenesis / Carcinogenesis / transcription complex / MADS-box and Homeobox

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