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Structure paper

TitleSTAG1 vulnerabilities for exploiting cohesin synthetic lethality in STAG2-deficient cancers.
Journal, issue, pagesLife Sci Alliance, Vol. 3, Year 2020
Publish dateDec 20, 2018 (structure data deposition date)
Authorsvan der Lelij, P. / Newman, J.A. / Lieb, S. / Jude, J. / Katis, V. / Hoffmann, T. / Hinterndorfer, M. / Bader, G. / Kraut, N. / Pearson, M.A. ...van der Lelij, P. / Newman, J.A. / Lieb, S. / Jude, J. / Katis, V. / Hoffmann, T. / Hinterndorfer, M. / Bader, G. / Kraut, N. / Pearson, M.A. / Peters, J.M. / Zuber, J. / Gileadi, O. / Petronczki, M.
External linksLife Sci Alliance / PubMed:32467316
MethodsX-ray diffraction
Resolution2.02 - 3.17 Å
Structure data

PDB-6qb5:
Crystal structure of the N-terminal region of human cohesin subunit STAG1
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-6r7o:
Crystal structure of the central region of human cohesin subunit STAG1
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-6rrc:
Crystal structure of the N-terminal region of human cohesin subunit STAG1 in complex with RAD21 peptide
Method: X-RAY DIFFRACTION / Resolution: 2.37 Å

PDB-6rrk:
Crystal structure of the central region of human cohesin subunit STAG1 in complex with RAD21 peptide
Method: X-RAY DIFFRACTION / Resolution: 3.17 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsGENE REGULATION / Cohesin / SA-1 / chromosome segregation / Stromal antigen / chromatid

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