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Structure paper

TitleStructural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Journal, issue, pagesNat Commun, Vol. 11, Page 2294-2294, Year 2020
Publish dateMar 20, 2020 (structure data deposition date)
AuthorsAnteneh, H. / Fang, J. / Song, J.
External linksNat Commun / PubMed:32385248
MethodsX-ray diffraction
Resolution2.4 - 2.598 Å
Structure data

PDB-6w89:
Structure of DNMT3A (R882H) in complex with CGA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.499 Å

PDB-6w8b:
Structure of DNMT3A in complex with CGA DNA
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6w8d:
Structure of DNMT3A (R882H) in complex with CGT DNA
Method: X-RAY DIFFRACTION / Resolution: 2.598 Å

PDB-6w8j:
Structure of DNMT3A (R882H) in complex with CAG DNA
Method: X-RAY DIFFRACTION / Resolution: 2.445 Å

Chemicals

ChemComp-CIT:
CITRIC ACID

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / DNA methylation / DNMT3A(R882H) / AML / epigenetics / TRANSFERASE / TRANSFERASE-DNA complex / DNMT3A

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