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Structure paper

TitleCryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 8692-8705, Year 2020
Publish dateSep 11, 2019 (structure data deposition date)
AuthorsRuskamo, S. / Krokengen, O.C. / Kowal, J. / Nieminen, T. / Lehtimaki, M. / Raasakka, A. / Dandey, V.P. / Vattulainen, I. / Stahlberg, H. / Kursula, P.
External linksJ. Biol. Chem. / PubMed:32265298
MethodsX-ray diffraction
Resolution1.65 - 3 Å
Structure data

PDB-6sts:
Human myelin protein P2 mutant R30Q
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-6xu5:
Human myelin protein P2 mutant N2D
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-6xu9:
Human myelin protein P2 mutant K3N
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6xua:
Human myelin protein P2 mutant K21Q
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6xuw:
Human myelin protein P2 mutant L27D
Method: X-RAY DIFFRACTION / Resolution: 2.31 Å

PDB-6xvq:
Human myelin protein P2 mutant K31Q
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6xvr:
Human myelin protein P2 mutant L35S
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6xvs:
Human myelin protein P2 mutant P38G, unliganded
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6xvy:
Human myelin protein P2 mutant R88Q
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-6xw9:
Human myelin protein P2 mutant K120S
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-PLM:
PALMITIC ACID

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-CIT:
CITRIC ACID

ChemComp-CL:
Unknown entry

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsLIPID BINDING PROTEIN / mutant / peripheral membrane protein / FABP / beta barrel

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