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Structure paper

TitleStructural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B.
Journal, issue, pagesNucleic Acids Res., Vol. 48, Page 3949-3961, Year 2020
Publish dateJul 1, 2019 (structure data deposition date)
AuthorsLin, C.C. / Chen, Y.P. / Yang, W.Z. / Shen, J.C.K. / Yuan, H.S.
External linksNucleic Acids Res. / PubMed:32083663
MethodsX-ray diffraction
Resolution2.862 - 3.274 Å
Structure data

PDB-6kda:
Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpG site
Method: X-RAY DIFFRACTION / Resolution: 2.909 Å

PDB-6kdb:
Crystal structure of human DNMT3B-DNMT3L in complex with DNA containing CpGpT site
Method: X-RAY DIFFRACTION / Resolution: 2.862 Å

PDB-6kdl:
Crystal structure of human DNMT3B-DNMT3L complex (I)
Method: X-RAY DIFFRACTION / Resolution: 3.274 Å

PDB-6kdp:
Crystal structure of human DNMT3B-DNMT3L complex (II)
Method: X-RAY DIFFRACTION / Resolution: 2.93 Å

PDB-6kdt:
Crystal structure of human DNMT3B (Q772R)-DNMT3L complex
Method: X-RAY DIFFRACTION / Resolution: 2.87 Å

Chemicals

ChemComp-SAH:
S-ADENOSYL-L-HOMOCYSTEINE

ChemComp-HOH:
WATER

ChemComp-FMT:
FORMIC ACID

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE/DNA / DNMT3B / DNA methyltransferase / complex / TRANSFERASE / TRANSFERASE-DNA complex

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