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TitleStructure of the AAVhu.37 capsid by cryoelectron microscopy.
Journal, issue, pagesActa Crystallogr F Struct Biol Commun, Vol. 76, Issue Pt 2, Page 58-64, Year 2020
Publish dateFeb 1, 2020
AuthorsJason T Kaelber / Samantha A Yost / Keith A Webber / Emre Firlar / Ye Liu / Olivier Danos / Andrew C Mercer /
PubMed AbstractAdeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV ...Adeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV serotypes and variants have been isolated from primate samples. Many reports have described unique properties of these variants (for instance, differences in potency, target cell or evasion of the immune response), despite high amino-acid sequence conservation. AAVhu.37 is of interest for clinical applications owing to its proficient transduction of the liver and central nervous system. The sequence identity of the AAVhu.37 VP1 to the well characterized AAVrh.10 serotype, for which no structure is available, is greater than 98%. Here, the structure of the AAVhu.37 capsid at 2.56 Å resolution obtained via single-particle cryo-electron microscopy is presented.
External linksActa Crystallogr F Struct Biol Commun / PubMed:32039886 / PubMed Central
MethodsEM (single particle)
Resolution2.56 - 2.7 Å
Structure data

20693

6u95

EMDB-20693, PDB-6u95:
Adeno-associated virus strain AAVhu.37 capsid icosahedral structure
Method: EM (single particle) / Resolution: 2.56 Å

22412

7jot

EMDB-22412, PDB-7jot:
Adeno-associated virus strain AAV7 capsid icosahedral structure
Method: EM (single particle) / Resolution: 2.7 Å

Source
  • adeno-associated virus
  • adeno-associated virus - 7
KeywordsVIRUS / capsid / blood-brain barrier penetration / AAV / parvovirus / Parvoviridae / adeno-associated virus

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