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Structure paper

TitleModulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT 3 receptor via a common vestibule site.
Journal, issue, pagesElife, Vol. 9, Year 2020
Publish dateSep 7, 2019 (structure data deposition date)
AuthorsBrams, M. / Govaerts, C. / Kambara, K. / Price, K.L. / Spurny, R. / Gharpure, A. / Pardon, E. / Evans, G.L. / Bertrand, D. / Lummis, S.C. ...Brams, M. / Govaerts, C. / Kambara, K. / Price, K.L. / Spurny, R. / Gharpure, A. / Pardon, E. / Evans, G.L. / Bertrand, D. / Lummis, S.C. / Hibbs, R.E. / Steyaert, J. / Ulens, C.
External linksElife / PubMed:31990273
MethodsX-ray diffraction
Resolution2.59 - 3.25 Å
Structure data

PDB-6ssi:
Structure of the pentameric ligand-gated ion channel ELIC in complex with a PAM nanobody
Method: X-RAY DIFFRACTION / Resolution: 2.59 Å

PDB-6ssp:
Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody
Method: X-RAY DIFFRACTION / Resolution: 3.25 Å

Chemicals

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-CA:
Unknown entry

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-UMQ:
UNDECYL-MALTOSIDE / detergent*YM

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • dickeya chrysanthemi (bacteria)
  • lama glama (llama)
KeywordsTRANSPORT PROTEIN / ION CHANNEL / CYS-LOOP RECEPTOR / PENTAMERIC LIGAND GATED ION CHANNEL / LGIC / ELIC / NANOBODY

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