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TitleTargeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development.
Journal, issue, pagesNat. Chem. Biol., Vol. 16, Page 31-41, Year 2020
Publish dateMar 28, 2019 (structure data deposition date)
AuthorsLim, S. / Cho, H.Y. / Kim, D.G. / Roh, Y. / Son, S.Y. / Mushtaq, A.U. / Kim, M. / Bhattarai, D. / Sivaraman, A. / Lee, Y. ...Lim, S. / Cho, H.Y. / Kim, D.G. / Roh, Y. / Son, S.Y. / Mushtaq, A.U. / Kim, M. / Bhattarai, D. / Sivaraman, A. / Lee, Y. / Lee, J. / Yang, W.S. / Kim, H.K. / Kim, M.H. / Lee, K. / Jeon, Y.H. / Kim, S.
External linksNat. Chem. Biol. / PubMed:31792442
MethodsX-ray diffraction
Resolution1.3981426881 - 2.15000649024 Å
Structure data

PDB-6jpv:
Structural analysis of AIMP2-DX2 and HSP70 interaction
Method: X-RAY DIFFRACTION / Resolution: 2.15000649024 Å

PDB-6k39:
Structural analysis of AIMP2-DX2 and HSP70 interaction
Method: X-RAY DIFFRACTION / Resolution: 1.3981426881 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCHAPERONE / HSP70 / AIMP2-DX2 / substrate binding domain

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