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Structure paper

TitlePotent antibody lineage against malaria transmission elicited by human vaccination with Pfs25.
Journal, issue, pagesNat Commun, Vol. 10, Page 4328-4328, Year 2019
Publish dateJun 25, 2019 (structure data deposition date)
AuthorsMcLeod, B. / Miura, K. / Scally, S.W. / Bosch, A. / Nguyen, N. / Shin, H. / Kim, D. / Volkmuth, W. / Ramisch, S. / Chichester, J.A. ...McLeod, B. / Miura, K. / Scally, S.W. / Bosch, A. / Nguyen, N. / Shin, H. / Kim, D. / Volkmuth, W. / Ramisch, S. / Chichester, J.A. / Streatfield, S. / Woods, C. / Schief, W.R. / Emerling, D. / King, C.R. / Julien, J.P.
External linksNat Commun / PubMed:31551421
MethodsX-ray diffraction
Resolution2 - 3.1 Å
Structure data

PDB-6phb:
Pfs25 in complex with the human transmission blocking antibody 2530
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6phc:
Pfs25 in complex with the human transmission blocking antibody 2544
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6phd:
Pfs25 in complex with the human transmission blocking antibody 2586
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-6phf:
Pfs25 in complex with the human transmission blocking antibody 2587
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

PDB-6phg:
Predicted germline variant of human transmission blocking antibody 2544
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6phh:
Unliganded human transmission blocking antibody 2544
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • plasmodium falciparum (malaria parasite P. falciparum)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Fab / Complex / Antigen / Immunoglobulin

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