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TitleStructural basis for neutralization of Plasmodium vivax by naturally acquired human antibodies that target DBP.
Journal, issue, pagesNat Microbiol, Vol. 4, Page 1486-1496, Year 2019
Publish dateMar 18, 2019 (structure data deposition date)
AuthorsUrusova, D. / Carias, L. / Huang, Y. / Nicolete, V.C. / Popovici, J. / Roesch, C. / Salinas, N.D. / Witkowski, B. / Ferreira, M.U. / Adams, J.H. ...Urusova, D. / Carias, L. / Huang, Y. / Nicolete, V.C. / Popovici, J. / Roesch, C. / Salinas, N.D. / Witkowski, B. / Ferreira, M.U. / Adams, J.H. / Gross, M.L. / King, C.L. / Tolia, N.H.
External linksNat Microbiol / PubMed:31133752
MethodsX-ray diffraction
Resolution2.9 - 3.497 Å
Structure data

PDB-6oan:
Structure of DBP in complex with human neutralizing antibody 053054
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6oao:
Structure of DBP in complex with human neutralizing antibody 092096
Method: X-RAY DIFFRACTION / Resolution: 3.497 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • plasmodium vivax (malaria parasite P. vivax)
  • homo sapiens (human)
KeywordsCELL INVASION / Plasmodium / vivax / Duffy Binding Protein / DBP / PvDBP / antibody / neutralizing / inhibition / malaria / invasion / blocking / vaccine / structural vaccinology

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