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Structure paper

TitleCrystal structures of Ca2+-calmodulin bound to NaVC-terminal regions suggest role for EF-hand domain in binding and inactivation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 10763-10772, Year 2019
Publish dateOct 23, 2018 (structure data deposition date)
AuthorsGardill, B.R. / Rivera-Acevedo, R.E. / Tung, C.C. / Van Petegem, F.
External linksProc. Natl. Acad. Sci. USA / PubMed:31072926
MethodsX-ray diffraction
Resolution1.9 - 2.69 Å
Structure data

PDB-6mud:
Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-6mue:
Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • rattus norvegicus (Norway rat)
KeywordsCALCIUM BINDING/TRANSPORT PROTEIN / voltage-gated ion channel / transport protein / EF-hand domain / CALCIUM BINDING-TRANSPORT PROTEIN complex / IQ domain

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