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Structure paper

TitleStructural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants.
Journal, issue, pagesJ. Mol. Biol., Vol. 431, Page 2213-2221, Year 2019
Publish dateNov 8, 2018 (structure data deposition date)
AuthorsOstertag, M.S. / Hutwelker, W. / Plettenburg, O. / Sattler, M. / Popowicz, G.M.
External linksJ. Mol. Biol. / PubMed:31026449
MethodsX-ray diffraction
Resolution1.81 - 2.2 Å
Structure data

PDB-6i41:
Co-crystal structure of human SPOP MATH domain (wild-type) and human BRD3 fragment
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6i5p:
Co-crystal structure of human SPOP MATH domain (E47K) and human BRD3 fragment
Method: X-RAY DIFFRACTION / Resolution: 1.81 Å

PDB-6i68:
Co-crystal structure of human SPOP MATH domain (M117V) and human BRD3 fragment
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-6i7a:
Co-crystal structure of human SPOP MATH domain (D140N) and human BRD3 fragment
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / ligase nuclear cancer ubiquitination

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