EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.
ジャーナル・号・ページ	Eur. J. Med. Chem., Vol. 173, Page 154-166, Year 2019
掲載日	2018年8月9日 (構造データの登録日)
著者	Nautiyal, M. / De Graef, S. / Pang, L. / Gadakh, B. / Strelkov, S.V. / Weeks, S.D. / Van Aerschot, A.
リンク	Eur. J. Med. Chem. / PubMed:30995568
手法	X線回折
解像度	1.88 - 2.31 Å
構造データ	PDB-6hb5: Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-cytidine 手法: X-RAY DIFFRACTION / 解像度: 1.88 Å PDB-6hb6: Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-uridine 手法: X-RAY DIFFRACTION / 解像度: 1.92 Å PDB-6hb7: Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6i5y: Crystal structure of E. coli tyrRS in complex with 5'-O-(N-L-tyrosyl)sulfamoyl-adenosine 手法: X-RAY DIFFRACTION / 解像度: 1.9 Å PDB-6q89: Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with the Intermediate Analog 5'-O-(N-(L-Leucyl)-Sulfamoyl)Adenosine 手法: X-RAY DIFFRACTION / 解像度: 2.21 Å PDB-6q8a: Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine 手法: X-RAY DIFFRACTION / 解像度: 2.11 Å PDB-6q8b: Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)N3-methyluridine 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-6q8c: Neisseria gonorrhoeae Leucyl-tRNA Synthetase in Complex with 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å
化合物	ChemComp-YSC: [(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル ChemComp-CL: Unknown entry / クロリド ChemComp-HOH: WATER ChemComp-YSU: [(2~{R},3~{S},4~{R},5~{R})-5-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate ChemComp-Y3U: [(2~{R},3~{S},4~{R},5~{R})-5-[3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-3-(4-hydroxyphenyl)propanoyl]sulfamate ChemComp-YSA: 5'-O-[N-(L-TYROSYL)SULFAMOYL]ADENOSINE / 5′-O-(L-Tyr-アミノスルホニル)アデノシン ChemComp-LSS: 5'-O-(L-leucylsulfamoyl)adenosine / 5′-O-(L-Leu-アミノスルホニル)アデノシン ChemComp-ZN: Unknown entry ChemComp-MG: Unknown entry / マグネシウムジカチオン ChemComp-HQ5: 5'-O-(N-(L-Leucyl)-Sulfamoyl)Cytidine ChemComp-L3U: [(2~{R},3~{S},4~{R},5~{R})-5-[3-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(2~{S})-2-azanyl-4-methyl-pentanoyl]sulfamate ChemComp-LSU: 5'-O-(N-(L-Leucyl)-Sulfamoyl)Uridine
由来	escherichia coli (strain b / bl21-de3) (大腸菌) escherichia coli bl21(de3) (大腸菌) neisseria gonorrhoeae (淋菌) neisseria gonorrhoeae (strain nccp11945) (淋菌)
キーワード	LIGASE / protein-inhibitor complex / Rossmann fold / tRNA aminoacylation / tRNA synthetase