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-Structure paper
Title | MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 116, Page 7533-7542, Year 2019 |
Publish date | Oct 21, 2018 (structure data deposition date) |
Authors | Casaletto, J.B. / Geddie, M.L. / Abu-Yousif, A.O. / Masson, K. / Fulgham, A. / Boudot, A. / Maiwald, T. / Kearns, J.D. / Kohli, N. / Su, S. ...Casaletto, J.B. / Geddie, M.L. / Abu-Yousif, A.O. / Masson, K. / Fulgham, A. / Boudot, A. / Maiwald, T. / Kearns, J.D. / Kohli, N. / Su, S. / Razlog, M. / Raue, A. / Kalra, A. / Hakansson, M. / Logan, D.T. / Welin, M. / Chattopadhyay, S. / Harms, B.D. / Nielsen, U.B. / Schoeberl, B. / Lugovskoy, A.A. / MacBeath, G. |
External links | Proc. Natl. Acad. Sci. USA / PubMed:30898885 |
Methods | X-ray diffraction |
Resolution | 2.31 - 3.1 Å |
Structure data | PDB-6hyg: PDB-6i04: PDB-6i07: |
Chemicals | ChemComp-ZN: ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | IMMUNE SYSTEM / immunoglobulin / Fc / MET / Sema domain / single chain Fv / scFv / EpCAM |