タイトル Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. ジャーナル・号・ページ Bioorg. Med. Chem. Lett. , Vol. 29, Page 1023-1029, Year 2019掲載日 2018年10月27日 (構造データの登録日) 著者Francis, S. / Croft, D. / Schuttelkopf, A.W. / Parry, C. / Pugliese, A. / Cameron, K. / Claydon, S. / Drysdale, M. / Gardner, C. / Gohlke, A. ...Francis, S. / Croft, D. / Schuttelkopf, A.W. / Parry, C. / Pugliese, A. / Cameron, K. / Claydon, S. / Drysdale, M. / Gardner, C. / Gohlke, A. / Goodwin, G. / Gray, C.H. / Konczal, J. / McDonald, L. / Mezna, M. / Pannifer, A. / Paul, N.R. / Machesky, L. / McKinnon, H. / Bower, J. リンク Bioorg. Med. Chem. Lett. / PubMed:30773430手法 X線回折 解像度 1.49 - 2.1 Å 構造データ PDB-6i0z : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 1 手法 : X-RAY DIFFRACTION / 解像度 : 1.77 Å
PDB-6i10 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 2 手法 : X-RAY DIFFRACTION / 解像度 : 2.1 Å
PDB-6i11 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 3 手法 : X-RAY DIFFRACTION / 解像度 : 1.67 Å
PDB-6i12 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 5 手法 : X-RAY DIFFRACTION / 解像度 : 1.65 Å
PDB-6i13 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 7 手法 : X-RAY DIFFRACTION / 解像度 : 1.79 Å
PDB-6i14 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 9 手法 : X-RAY DIFFRACTION / 解像度 : 1.73 Å
PDB-6i15 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 11 手法 : X-RAY DIFFRACTION / 解像度 : 1.91 Å
PDB-6i16 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 15 手法 : X-RAY DIFFRACTION / 解像度 : 2 Å
PDB-6i17 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH COMPOUND 24 手法 : X-RAY DIFFRACTION / 解像度 : 1.56 Å
PDB-6i18 : 構造ビューア CRYSTAL STRUCTURE OF FASCIN IN COMPLEX WITH BDP-13176 手法 : X-RAY DIFFRACTION / 解像度 : 1.49 Å
化合物 ChemComp-GZQ : 構造ビューア ~{N}-(2,4-dichlorophenyl)-~{N}-methyl-ethanamide
ChemComp-GZK : 構造ビューア 1-[(3~{R})-1,1-bis(oxidanylidene)thiolan-3-yl]-5-[(3,4-dichlorophenyl)methyl]pyrazolo[3,4-d]pyrimidin-4-one
ChemComp-H0H : 構造ビューア ~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-2-(phenylmethyl)isoquinoline-4-carboxamide
ChemComp-H08 : 構造ビューア 2-[(4-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
ChemComp-H0Q : 構造ビューア 2-[(3-chlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
ChemComp-GZN : 構造ビューア 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-isoquinoline-4-carboxamide
ChemComp-GZT : 構造ビューア 1-[[2,2-bis(fluoranyl)-1,3-benzodioxol-5-yl]methyl]-~{N}-methyl-2-oxidanylidene-pyridine-3-carboxamide
ChemComp-H0B : 構造ビューア 6-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-5-oxidanylidene-1,6-naphthyridine-8-carboxamide
ChemComp-GZW : 構造ビューア 2-[(3,4-dichlorophenyl)methyl]-~{N}-(1-methylpyrazol-4-yl)-1-oxidanylidene-6-piperidin-4-yl-2,7-naphthyridine-4-carboxamide
ChemComp-H0N : 構造ビューア 5-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-1-piperidin-4-yl-~{N}-pyridin-4-yl-pyrazolo[4,3-c]pyridine-7-carboxamide
由来 homo sapiens (ヒト) キーワード STRUCTURAL PROTEIN / actin bundling / small molecule inhibition