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Structure paper

TitleStructural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 4608-4620, Year 2019
Publish dateApr 13, 2017 (structure data deposition date)
AuthorsMero, B. / Radnai, L. / Gogl, G. / Toke, O. / Leveles, I. / Koprivanacz, K. / Szeder, B. / Dulk, M. / Kudlik, G. / Vas, V. ...Mero, B. / Radnai, L. / Gogl, G. / Toke, O. / Leveles, I. / Koprivanacz, K. / Szeder, B. / Dulk, M. / Kudlik, G. / Vas, V. / Cserkaszky, A. / Sipeki, S. / Nyitray, L. / Vertessy, B.G. / Buday, L.
External linksJ. Biol. Chem. / PubMed:30659095
MethodsX-ray diffraction
Resolution1.4 - 2 Å
Structure data

PDB-5np2:
Abl1 SH3 pTyr89/134
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-5np3:
Abl2 SH3
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5np5:
Abl2 SH3 pTyr116/161
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / signaling / tyrosine phosphorylation / SH3 domain / kinase

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