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TitleStructures of Coxsackievirus A10 unveil the molecular mechanisms of receptor binding and viral uncoating.
Journal, issue, pagesNat Commun, Vol. 9, Issue 1, Page 4985, Year 2018
Publish dateNov 26, 2018
AuthorsLing Zhu / Yao Sun / Jinyan Fan / Bin Zhu / Lei Cao / Qiang Gao / Yanjun Zhang / Hongrong Liu / Zihe Rao / Xiangxi Wang /
PubMed AbstractCoxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, ...Coxsackievirus A10 (CVA10), a human type-A Enterovirus (HEV-A), can cause diseases ranging from hand-foot-and-mouth disease to polio-myelitis-like disease. CVA10, together with some other HEV-As, utilizing the molecule KREMEN1 as an entry receptor, constitutes a KREMEN1-dependent subgroup within HEV-As. Currently, there is no vaccine or antiviral therapy available for treating diseases caused by CVA10. The atomic-resolution structure of the CVA10 virion, which is within the KREMEN1-dependent subgroup, shows significant conformational differences in the putative receptor binding sites and serotype-specific epitopes, when compared to the SCARB2-dependent subgroup of HEV-A, such as EV71, highlighting specific differences between the sub-groups. We also report two expanded structures of CVA10, an empty particle and uncoating intermediate at atomic resolution, as well as a medium-resolution genome structure reconstructed using a symmetry-mismatch method. Structural comparisons coupled with previous results, reveal an ordered signal transmission process for enterovirus uncoating, converting exo-genetic receptor-attachment inputs into a generic RNA release mechanism.
External linksNat Commun / PubMed:30478256 / PubMed Central
MethodsEM (single particle)
Resolution2.7 - 12.0 Å
Structure data

9642

6aks

EMDB-9642, PDB-6aks:
Cryo-EM structure of CVA10 mature virus
Method: EM (single particle) / Resolution: 3.0 Å

9643

6akt

EMDB-9643, PDB-6akt:
Cryo-EM structure of CVA10 A-particle
Method: EM (single particle) / Resolution: 2.8 Å

9644

6aku

EMDB-9644, PDB-6aku:
Cryo-EM structure of CVA10 empty particle
Method: EM (single particle) / Resolution: 2.7 Å

EMDB-9652:
Asymmetrical reconstruction of CVA10 A-particle
Method: EM (single particle) / Resolution: 12.0 Å

Chemicals

ChemComp-SPH:
SPHINGOSINE / Sphingosine

Source
  • coxsackievirus a10
KeywordsVIRUS / picornavirus uncoating / receptor binding

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