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-Structure paper
Title | Cell-Active Small Molecule Inhibitors of the DNA-Damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides. |
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Journal, issue, pages | J. Med. Chem., Vol. 61, Page 10767-10792, Year 2018 |
Publish date | Sep 12, 2018 (structure data deposition date) |
![]() | Waszkowycz, B. / Smith, K.M. / McGonagle, A.E. / Jordan, A.M. / Acton, B. / Fairweather, E.E. / Griffiths, L.A. / Hamilton, N.M. / Hamilton, N.S. / Hitchin, J.R. ...Waszkowycz, B. / Smith, K.M. / McGonagle, A.E. / Jordan, A.M. / Acton, B. / Fairweather, E.E. / Griffiths, L.A. / Hamilton, N.M. / Hamilton, N.S. / Hitchin, J.R. / Hutton, C.P. / James, D.I. / Jones, C.D. / Jones, S. / Mould, D.P. / Small, H.F. / Stowell, A.I.J. / Tucker, J.A. / Waddell, I.D. / Ogilvie, D.J. |
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Methods | X-ray diffraction |
Resolution | 1.9 - 2.87 Å |
Structure data | ![]() PDB-6hmk: ![]() PDB-6hml: ![]() PDB-6hmm: ![]() PDB-6hmn: |
Chemicals | ![]() ChemComp-DMS: ![]() ChemComp-GOL: ![]() ChemComp-SO4: ![]() ChemComp-7JC: ![]() ChemComp-HOH: ![]() ChemComp-73L: ![]() ChemComp-7JB: ![]() ChemComp-70J: |
Source |
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![]() | HYDROLASE / COMPETITIVE INHIBITOR / PARG |