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TitleStructural insights into inhibitor binding to a fungal ortholog of aspartate semialdehyde dehydrogenase.
Journal, issue, pagesBiochem. Biophys. Res. Commun., Vol. 503, Page 2848-2854, Year 2018
Publish dateJan 24, 2018 (structure data deposition date)
AuthorsDahal, G.P. / Viola, R.E.
External linksBiochem. Biophys. Res. Commun. / PubMed:30107909
MethodsX-ray diffraction
Resolution2.4 - 2.6 Å
Structure data

PDB-6c85:
Crystal structure of aspartate semialdehyde dehydrogenase from Blastomyces dermatitidis with p-benzoquinone
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6c8w:
Crystal structure of Aspartate Semialdehyde Dehydrogenase with NADP from Blastomyces dermatitidis
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-PLQ:
1,4-benzoquinone

ChemComp-HOH:
WATER

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

Source
  • blastomyces gilchristii (fungus)
KeywordsOXIDOREDUCTASE / Rossman fold / Antifungal inhibitor complex / NADP cofactor

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