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TitleStructure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.
Journal, issue, pagesCell, Vol. 174, Issue 5, Page 1117-1126.e12, Year 2018
Publish dateAug 23, 2018
AuthorsQianhui Qu / Yoh-Hei Takahashi / Yidai Yang / Hongli Hu / Yan Zhang / Joseph S Brunzelle / Jean-Francois Couture / Ali Shilatifard / Georgios Skiniotis /
PubMed AbstractThe methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity ...The methylation of histone 3 lysine 4 (H3K4) is carried out by an evolutionarily conserved family of methyltransferases referred to as complex of proteins associated with Set1 (COMPASS). The activity of the catalytic SET domain (su(var)3-9, enhancer-of-zeste, and trithorax) is endowed through forming a complex with a set of core proteins that are widely shared from yeast to humans. We obtained cryo-electron microscopy (cryo-EM) maps of the yeast Set1/COMPASS core complex at overall 4.0- to 4.4-Å resolution, providing insights into its structural organization and conformational dynamics. The Cps50 C-terminal tail weaves within the complex to provide a central scaffold for assembly. The SET domain, snugly positioned at the junction of the Y-shaped complex, is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3). The mobile SET-I motif of the SET domain is engaged by Cps30, explaining its key role in COMPASS catalytic activity toward higher H3K4 methylation states.
External linksCell / PubMed:30100186 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.818 - 4.3 Å
Structure data

7303

6bx3

EMDB-7303, PDB-6bx3:
Structure of histone H3k4 methyltransferase
Method: EM (single particle) / Resolution: 4.3 Å

PDB-6e29:
Crystal structure of Myceliophteria_thermophila Cps50 (Swd1) beta-propeller domain
Method: X-RAY DIFFRACTION / Resolution: 1.818 Å

Chemicals

ChemComp-HOH:
WATER / Water

Source
  • Saccharomyces cerevisiae (brewer's yeast)
  • saccharomyces cerevisiae (strain yjm789) (yeast)
  • saccharomyces cerevisiae (strain atcc 204508 / s288c) (yeast)
  • myceliophthora thermophila (fungus)
KeywordsGENE REGULATION/Transferase / Histone H3K4 Methyltransferase / GENE REGULATION-Transferase complex / PROTEIN BINDING / histone / epigenetics / COMPASS / histone H3 Lys-4 methylation / MLL1 / SET1

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