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Structure paper

TitleStructural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Journal, issue, pagesNat Commun, Vol. 9, Page 3085-3085, Year 2018
Publish dateFeb 27, 2018 (structure data deposition date)
AuthorsChen, S.F. / Huang, N.L. / Lin, J.H. / Wu, C.C. / Wang, Y.R. / Yu, Y.J. / Gilson, M.K. / Chan, N.L.
External linksNat Commun / PubMed:30082834
MethodsX-ray diffraction
Resolution2.3 - 3.873 Å
Structure data

PDB-5zen:
Crystal structure of human topoisomerase II beta in complex with DNA: a new quaternary conformation showing opening of the protein-linked DNA-gate
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-5zqf:
Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA in space group P3221
Method: X-RAY DIFFRACTION / Resolution: 3.873 Å

PDB-5zrf:
Crystal structure of human topoisomerase II beta in complex with 5-iodouridine-containing-DNA and etoposide in space group p21
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-EVP:
(5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol / medication, chemotherapy*YM

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsISOMERASE/DNA / Type II topoisomerase / cleavage complex / DNA-gate / ISOMERASE-DNA complex / Anti-cancer drug / TopoII cleavage complex / ISOMERASE-DNA-ISOMERASE INHIBITOR complex

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