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TitleA Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases.
Journal, issue, pagesStructure, Vol. 26, Page 1226-, Year 2018
Publish dateDec 12, 2017 (structure data deposition date)
AuthorsGorelik, M. / Manczyk, N. / Pavlenco, A. / Kurinov, I. / Sidhu, S.S. / Sicheri, F.
External linksStructure / PubMed:30033217
MethodsX-ray diffraction
Resolution2.61 - 3.27 Å
Structure data

PDB-6bva:
Ubiquitin Variant (UbV.Fl10.1) bound to a human Skp1-Fbl10 fragment complex.
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-6byh:
Ubiquitin Variant (UbV.Fl11.1) bound to a human Skp1-Fbl11 fragment complex.
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-6c16:
Ubiquitin variant (UbV.Fbl10.1) bound to a human Skp1-Fbl11 fragment complex.
Method: X-RAY DIFFRACTION / Resolution: 3.27 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Ubiquitination

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