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TitleStructures of ubiquitin-like (Ubl) and Hsp90-like domains of sacsin provide insight into pathological mutations.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 12832-12842, Year 2018
Publish dateMar 8, 2017 (structure data deposition date)
AuthorsMenade, M. / Kozlov, G. / Trempe, J.F. / Pande, H. / Shenker, S. / Wickremasinghe, S. / Li, X. / Hojjat, H. / Dicaire, M.J. / Brais, B. ...Menade, M. / Kozlov, G. / Trempe, J.F. / Pande, H. / Shenker, S. / Wickremasinghe, S. / Li, X. / Hojjat, H. / Dicaire, M.J. / Brais, B. / McPherson, P.S. / Wong, M.J.H. / Young, J.C. / Gehring, K.
External linksJ. Biol. Chem. / PubMed:29945973
MethodsX-ray diffraction
Resolution1.56 - 2.4 Å
Structure data

PDB-5v44:
Crystal structure of the SR1 domain of human sacsin
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-5v45:
Crystal structure of the F270M, K291M, L318M mutant of SR1 domain of human sacsin
Method: X-RAY DIFFRACTION / Resolution: 1.91 Å

PDB-5v46:
Crystal structure of the I113M, F270M, K291M, L308M mutant of SR1 domain of human sacsin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5v47:
Crystal structure of the SR1 domain of lizard sacsin
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

PDB-5vsx:
Structure of the Ubl domain of Sacsin
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5vsz:
Structure of the Ubl domain of Sacsin mutant L78M
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • anolis carolinensis (green anole)
KeywordsCHAPERONE / alpha-beta sandwich / Bergerat fold / ubiquitin-like

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