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Structure paper

TitleDual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists Specifically Optimized for Multidose Formulations.
Journal, issue, pagesJ. Med. Chem., Vol. 61, Page 5580-5593, Year 2018
Publish dateApr 13, 2018 (structure data deposition date)
AuthorsEvers, A. / Bossart, M. / Pfeiffer-Marek, S. / Elvert, R. / Schreuder, H. / Kurz, M. / Stengelin, S. / Lorenz, M. / Herling, A. / Konkar, A. ...Evers, A. / Bossart, M. / Pfeiffer-Marek, S. / Elvert, R. / Schreuder, H. / Kurz, M. / Stengelin, S. / Lorenz, M. / Herling, A. / Konkar, A. / Lukasczyk, U. / Pfenninger, A. / Lorenz, K. / Haack, T. / Kadereit, D. / Wagner, M.
External linksJ. Med. Chem. / PubMed:29879354
MethodsX-ray diffraction / NMR (solution)
Resolution2.73 Å
Structure data

PDB-6gb1:
Crystal structure of the GLP1 receptor ECD with Peptide 11
Method: X-RAY DIFFRACTION / Resolution: 2.73 Å

PDB-6gdz:
exendin-4 based dual GLP-1/glucagon receptor agonist
Method: SOLUTION NMR

PDB-6ge2:
exendin-4 based dual GLP-1/glucagon receptor agonist
Method: SOLUTION NMR

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HEZ:
HEXANE-1,6-DIOL

ChemComp-HOH:
WATER

ChemComp-EVT:
(2~{S})-2-[[(4~{S})-4-(hexadecanoylamino)-5-oxidanyl-5-oxidanylidene-pentanoyl]amino]pentanedioic acid

Source
  • homo sapiens (human)
  • synthetic construct (others)
  • heloderma suspectum (Gila monster)
KeywordsPEPTIDE BINDING PROTEIN / Glucagon-like Peptide 1 Protein-Peptide complex Incretins Diabetes drug discovery / HORMONE

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