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Structure paper

TitleTemplate-Catalyzed, Disulfide Conjugation of Monoclonal Antibodies Using a Natural Amino Acid Tag.
Journal, issue, pagesBioconjug. Chem., Vol. 29, Page 2074-2081, Year 2018
Publish dateOct 11, 2017 (structure data deposition date)
AuthorsKing, J.D. / Ma, Y. / Kuo, Y.C. / Bzymek, K.P. / Goodstein, L.H. / Meyer, K. / Moore, R.E. / Crow, D. / Colcher, D.M. / Singh, G. ...King, J.D. / Ma, Y. / Kuo, Y.C. / Bzymek, K.P. / Goodstein, L.H. / Meyer, K. / Moore, R.E. / Crow, D. / Colcher, D.M. / Singh, G. / Horne, D.A. / Williams, J.C.
External linksBioconjug. Chem. / PubMed:29763554
MethodsX-ray diffraction
Resolution1.82 - 2.14 Å
Structure data

PDB-6b9y:
Trastuzumab Fab v3 in complex with 5-phenyl meditope variant
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

PDB-6b9z:
Trastuzumab Fab v3
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-6bae:
Trastuzumab Fab v3 in complex with CQFDLSTRRLKC
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

PDB-6bah:
Trastuzumab Fab v3 with 5-diphenyl meditope variant
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • finegoldia magna (bacteria)
  • staphylococcus aureus (bacteria)
  • synthetic construct (others)
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / monoclonal antibody / Fab / meditope

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