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Structure paper

TitleVaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses.
Journal, issue, pagesNat Commun, Vol. 9, Page 1884-1884, Year 2018
Publish dateJun 3, 2017 (structure data deposition date)
AuthorsClark, L.E. / Mahmutovic, S. / Raymond, D.D. / Dilanyan, T. / Koma, T. / Manning, J.T. / Shankar, S. / Levis, S.C. / Briggiler, A.M. / Enria, D.A. ...Clark, L.E. / Mahmutovic, S. / Raymond, D.D. / Dilanyan, T. / Koma, T. / Manning, J.T. / Shankar, S. / Levis, S.C. / Briggiler, A.M. / Enria, D.A. / Wucherpfennig, K.W. / Paessler, S. / Abraham, J.
External linksNat Commun / PubMed:29760382
MethodsX-ray diffraction
Resolution2 - 3.99 Å
Structure data

PDB-5w1g:
CR1-07 unliganded Fab
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5w1k:
JUNV GP1 CR1-10 Fab CR1-28 Fab complex
Method: X-RAY DIFFRACTION / Resolution: 3.99 Å

PDB-5w1m:
MACV GP1 CR1-07 Fab complex
Method: X-RAY DIFFRACTION / Resolution: 3.91 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-BMA:
beta-D-mannopyranose

Source
  • homo sapiens (human)
  • junin mammarenavirus
  • machupo virus
KeywordsIMMUNE SYSTEM / Fab / antibody / Machupo virus / Junin virus / arenavirus / VIRAL PROTEIN/IMMUNE SYSTEM / viral protein / VIRAL PROTEIN-IMMUNE SYSTEM complex

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