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TitleNear-atomic model of microtubule-tau interactions.
Journal, issue, pagesScience, Vol. 360, Issue 6394, Page 1242-1246, Year 2018
Publish dateJun 15, 2018
AuthorsElizabeth H Kellogg / Nisreen M A Hejab / Simon Poepsel / Kenneth H Downing / Frank DiMaio / Eva Nogales /
PubMed AbstractTau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into ...Tau is a developmentally regulated axonal protein that stabilizes and bundles microtubules (MTs). Its hyperphosphorylation is thought to cause detachment from MTs and subsequent aggregation into fibrils implicated in Alzheimer's disease. It is unclear which tau residues are crucial for tau-MT interactions, where tau binds on MTs, and how it stabilizes them. We used cryo-electron microscopy to visualize different tau constructs on MTs and computational approaches to generate atomic models of tau-tubulin interactions. The conserved tubulin-binding repeats within tau adopt similar extended structures along the crest of the protofilament, stabilizing the interface between tubulin dimers. Our structures explain the effect of phosphorylation on MT affinity and lead to a model of tau repeats binding in tandem along protofilaments, tethering together tubulin dimers and stabilizing polymerization interfaces.
External linksScience / PubMed:29748322 / PubMed Central
MethodsEM (helical sym.)
Resolution3.2 - 5.6 Å
Structure data

EMDB-7520:
cryo-EM reconstruction of microtubule-bound 2R-Tau
Method: EM (helical sym.) / Resolution: 5.6 Å

EMDB-7522:
cryo-EM reconstruction of microtubule-bound full-length Tau
Method: EM (helical sym.) / Resolution: 4.1 Å

EMDB-7523:
cryo-EM reconstruction of microtubule-bound 4R-tau
Method: EM (helical sym.) / Resolution: 4.8 Å

7769

6cvj

EMDB-7769: Cryo-EM reconstruction of synthetic tau: four tandem repeats of first repeat (R1) sequence, bound to the microtubule
PDB-6cvj: Model of synthetic tau (four tandem repeats of first repeat sequence) bound to the microtubule
Method: EM (helical sym.) / Resolution: 3.2 Å

7771

6cvn

EMDB-7771: Cryo-EM reconstruction of microtubule-bound synthetic (R2x4) tau
PDB-6cvn: Model of synthetic tau (R2x4) bound to the microtubule
Method: EM (helical sym.) / Resolution: 3.9 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM / Guanosine triphosphate

ChemComp-MG:
Unknown entry

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM / Guanosine diphosphate

Source
  • sus scrofa (pig)
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / microtubule / tau

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