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Structure paper

TitleTwo distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima.
Journal, issue, pagesElife, Vol. 7, Year 2018
Publish dateOct 21, 2015 (structure data deposition date)
AuthorsMorgunova, E. / Yin, Y. / Das, P.K. / Jolma, A. / Zhu, F. / Popov, A. / Xu, Y. / Nilsson, L. / Taipale, J.
External linksElife / PubMed:29638214
MethodsX-ray diffraction
Resolution2.195 - 3.2 Å
Structure data

PDB-5edn:
Structure of HOXB13-DNA(TCG) complex
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-5eea:
Structure of HOXB13-DNA(CAA) complex
Method: X-RAY DIFFRACTION / Resolution: 2.195 Å

PDB-6es2:
Structure of CDX2-DNA(CAA)
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-6es3:
Structure of CDX2-DNA(TCG)
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / transcription factor / DNA / complex / homeodomain transcription factor / CDX2-DNA complex

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