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Structure paper

TitleStructural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
Journal, issue, pagesJ. Biol. Chem., Vol. 293, Page 7344-7354, Year 2018
Publish dateJan 4, 2018 (structure data deposition date)
AuthorsLiu, K. / Xu, C. / Lei, M. / Yang, A. / Loppnau, P. / Hughes, T.R. / Min, J.
External linksJ. Biol. Chem. / PubMed:29567833
MethodsX-ray diffraction
Resolution1.84 - 2.3 Å
Structure data

PDB-6c1a:
MBD2 in complex with methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-6c1t:
MBD2 in complex with a partially methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 1.84 Å

PDB-6c1u:
MBD2 in complex with a deoxy-oligonucleotide
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6c1v:
MBD2 in complex with double-stranded DNA
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-6cnp:
Crystal structure of MBD2 complex with methylated CpG island
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-6cnq:
MBD2 in complex with methylated DNA
Method: X-RAY DIFFRACTION / Resolution: 2.151 Å

Chemicals

ChemComp-UNX:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN/DNA / dna methylation / dna binding / Structural Genomics / Structural Genomics Consortium / SGC / DNA BINDING PROTEIN-DNA complex / MBD / DNA-binding / TRANSCRIPTION/DNA / TRANSCRIPTION-DNA complex

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