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TitleStructural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Journal, issue, pagesGenes Dev., Vol. 32, Page 341-346, Year 2018
Publish dateFeb 28, 2018 (structure data deposition date)
AuthorsZhang, H. / Zhou, B. / Qin, S. / Xu, J. / Harding, R. / Tempel, W. / Nayak, V. / Li, Y. / Loppnau, P. / Dou, Y. / Min, J.
External linksGenes Dev. / PubMed:29563185
MethodsX-ray diffraction
Resolution2 - 2.49 Å
Structure data

PDB-6ckn:
Crystal structure of an AF10 fragment
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

PDB-6cko:
Crystal structure of an AF10 fragment
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-UNX:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • danio rerio (zebrafish)
KeywordsDNA BINDING PROTEIN / Structural Genomics / Structural Genomics Consortium / SGC / DNA BINDING PROTEIN/TRANSFERASE / DNA BINDING PROTEIN-TRANSFERASE complex

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