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Structure paper

TitleRelapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.
Journal, issue, pagesLeukemia, Vol. 32, Page 1393-1403, Year 2018
Publish dateAug 10, 2017 (structure data deposition date)
AuthorsHnizda, A. / Fabry, M. / Moriyama, T. / Pachl, P. / Kugler, M. / Brinsa, V. / Ascher, D.B. / Carroll, W.L. / Novak, P. / Zaliova, M. ...Hnizda, A. / Fabry, M. / Moriyama, T. / Pachl, P. / Kugler, M. / Brinsa, V. / Ascher, D.B. / Carroll, W.L. / Novak, P. / Zaliova, M. / Trka, J. / Rezacova, P. / Yang, J.J. / Veverka, V.
External linksLeukemia / PubMed:29535428
MethodsX-ray diffraction
Resolution1.68 - 2 Å
Structure data

PDB-5opk:
Crystal structure of D52N/R367Q cN-II mutant bound to dATP and free phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-5opl:
Crystal structure of K25E cN-II mutant
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-5opm:
Crystal structure of D52N/R238W cN-II mutant bound to dATP and free phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.68 Å

PDB-5opn:
Crystal structure of R39Q cN-II mutant
Method: X-RAY DIFFRACTION / Resolution: 1.77 Å

PDB-5opo:
Crystal structure of R238G cN-II mutant
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5opp:
Crystal structure of S408R cN-II mutant
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-HOH:
WATER

ChemComp-BR:
BROMIDE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / nucleotidase / relapsed leukemia

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