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Structure paper

TitleMolecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Journal, issue, pagesNat Commun, Vol. 9, Page 399-399, Year 2018
Publish dateJul 31, 2017 (structure data deposition date)
AuthorsWhitaker, A.M. / Flynn, T.S. / Freudenthal, B.D.
External linksNat Commun / PubMed:29374164
MethodsX-ray diffraction
Resolution2 - 2.6 Å
Structure data

PDB-5wn0:
APE1 exonuclease substrate complex with a C/G match
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-5wn1:
APE1 exonuclease product complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-5wn2:
APE1 exonuclease substrate complex with phosphoglycolate
Method: X-RAY DIFFRACTION / Resolution: 2.288 Å

PDB-5wn3:
APE1 F266A exonuclease substrate complex with a C/T mismatch
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-5wn4:
APE1 exonuclease substrate complex with a C/T mismatch
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-5wn5:
APE1 exonuclease substrate complex with a C/T mismatch and Mn2+
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PGA:
2-PHOSPHOGLYCOLIC ACID

ChemComp-MN:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / LYASE/DNA / LYASE-DNA complex

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