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TitleGeneration of specific inhibitors of SUMO-1- and SUMO-2/3-mediated protein-protein interactions using Affimer (Adhiron) technology.
Journal, issue, pagesSci Signal, Vol. 10, Year 2017
Publish dateNov 4, 2015 (structure data deposition date)
AuthorsHughes, D.J. / Tiede, C. / Penswick, N. / Tang, A.A. / Trinh, C.H. / Mandal, U. / Zajac, K.Z. / Gaule, T. / Howell, G. / Edwards, T.A. ...Hughes, D.J. / Tiede, C. / Penswick, N. / Tang, A.A. / Trinh, C.H. / Mandal, U. / Zajac, K.Z. / Gaule, T. / Howell, G. / Edwards, T.A. / Duan, J. / Feyfant, E. / McPherson, M.J. / Tomlinson, D.C. / Whitehouse, A.
External linksSci Signal / PubMed:29138295
MethodsX-ray diffraction
Resolution1.983 - 2.49 Å
Structure data

PDB-5elj:
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Method: X-RAY DIFFRACTION / Resolution: 1.983 Å

PDB-5elu:
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-5eql:
Isoform-specific inhibition of SUMO-dependent protein-protein interactions
Method: X-RAY DIFFRACTION / Resolution: 2.49 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • synthetic construct (others)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Ubiquitin / Sumoylation / PROTEIN BINDING

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