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Structure paper

TitleStructural insights of lincosamides targeting the ribosome of Staphylococcus aureus.
Journal, issue, pagesNucleic Acids Res., Vol. 45, Page 10284-10292, Year 2017
Publish dateJan 14, 2016 (structure data deposition date)
AuthorsMatzov, D. / Eyal, Z. / Benhamou, R.I. / Shalev-Benami, M. / Halfon, Y. / Krupkin, M. / Zimmerman, E. / Rozenberg, H. / Bashan, A. / Fridman, M. / Yonath, A.
External linksNucleic Acids Res. / PubMed:28973455
MethodsX-ray diffraction
Resolution3.442 - 3.66 Å
Structure data

PDB-5hkv:
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with lincomycin
Method: X-RAY DIFFRACTION / Resolution: 3.66 Å

PDB-5nrg:
The crystal structure of the large ribosomal subunit of Staphylococcus aureus in complex with RB02
Method: X-RAY DIFFRACTION / Resolution: 3.442 Å

Chemicals

ChemComp-3QB:
LINCOMYCIN / antibiotic*YM

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-MN:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-SPD:
SPERMIDINE

ChemComp-EOH:
ETHANOL

ChemComp-CA:
Unknown entry

ChemComp-95H:
~{N}-[(1~{R},2~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]-2-oxidanyl-propy

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

Source
  • staphylococcus aureus subsp. aureus nctc 8325 (bacteria)
  • staphylococcus aureus (strain nctc 8325) (bacteria)
KeywordsRIBOSOME / RNA / lincomycin / antibiotics / lincosamides

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