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TitleDifferential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins.
Journal, issue, pagesCell Rep, Vol. 20, Page 2876-2890, Year 2017
Publish dateFeb 24, 2017 (structure data deposition date)
AuthorsHayashi, T. / Senda, M. / Suzuki, N. / Nishikawa, H. / Ben, C. / Tang, C. / Nagase, L. / Inoue, K. / Senda, T. / Hatakeyama, M.
External linksCell Rep / PubMed:28930683
MethodsX-ray diffraction
Resolution2.45 - 2.6 Å
Structure data

PDB-5x7b:
Crystal structure of SHP2_SH2-CagA EPIYA_C peptide complex
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

PDB-5x94:
Crystal structure of SHP2_SH2-CagA EPIYA_D peptide complex
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • helicobacter pylori (bacteria)
KeywordsHYDROLASE / Helicobacter pylori CagA / SH2 domain-containing protein tyrosine phosphatase 2 (SHP2) / CagA polymorphism

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