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TitleEye patches: Protein assembly of index-gradient squid lenses.
Journal, issue, pagesScience, Vol. 357, Issue 6351, Page 564-569, Year 2017
Publish dateAug 11, 2017
AuthorsJ Cai / J P Townsend / T C Dodson / P A Heiney / A M Sweeney /
PubMed AbstractA parabolic relationship between lens radius and refractive index allows spherical lenses to avoid spherical aberration. We show that in squid, patchy colloidal physics resulted from an evolutionary ...A parabolic relationship between lens radius and refractive index allows spherical lenses to avoid spherical aberration. We show that in squid, patchy colloidal physics resulted from an evolutionary radiation of globular S-crystallin proteins. Small-angle x-ray scattering experiments on lens tissue show colloidal gels of S-crystallins at all radial positions. Sparse lens materials form via low-valence linkages between disordered loops protruding from the protein surface. The loops are polydisperse and bind via a set of hydrogen bonds between disordered side chains. Peripheral lens regions with low particle valence form stable, volume-spanning gels at low density, whereas central regions with higher average valence gel at higher densities. The proteins demonstrate an evolved set of linkers for self-assembly of nanoparticles into volumetric materials.
External linksScience / PubMed:28798124 / PubMed Central
MethodsSAS (X-ray synchrotron)
Structure data

SASDCQ5:
SAXS on intact Doryteuthis squid lens 100% layer (S-crystallin, Q25367_DOROP, S-crystallin, Q25367)
Method: SAXS/SANS

SASDCR5:
SAXS on intact Doryteuthis squid lens 80% layer (S-crystallin, Q25367_DOROP, S-crystallin, Q25367)
Method: SAXS/SANS

SASDCS5:
SAXS on intact Doryteuthis squid lens 60% layer (S-crystallin, Q25367_DOROP, S-crystallin, Q25367)
Method: SAXS/SANS

SASDCT5:
SAXS on intact Doryteuthis squid lens 40% layer (S-crystallin, Q25367_DOROP, S-crystallin, Q25367)
Method: SAXS/SANS

SASDCU5: SAXS dilution series on ground Doryteuthis squid lens 100% layer
Method: SAXS/SANS

Source
  • Doryteuthis pealeii (longfin inshore squid)

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