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Title2-Alkylquinolone alkaloid biosynthesis in the medicinal plant Evodia rutaecarpa involves collaboration of two novel type III polyketide synthases
Journal, issue, pagesJ. Biol. Chem., Vol. 292, Page 9117-9135, Year 2017
Publish dateJan 6, 2017 (structure data deposition date)
AuthorsMatsui, T. / Kodama, T. / Mori, T. / Tadakoshi, T. / Noguchi, H. / Abe, I. / Morita, H.
External linksJ. Biol. Chem. / PubMed:28411241
MethodsX-ray diffraction
Resolution1.799 - 3.058 Å
Structure data

PDB-5wx3:
Alkyldiketide-CoA synthase from Evodia rutaecarpa
Method: X-RAY DIFFRACTION / Resolution: 1.801 Å

PDB-5wx4:
Alkylquinolone synthase from Evodia rutaecarpa
Method: X-RAY DIFFRACTION / Resolution: 2.203 Å

PDB-5wx5:
Alkylquinolone synthase Y215V mutant from Evodia rutaecarpa
Method: X-RAY DIFFRACTION / Resolution: 3.058 Å

PDB-5wx6:
Alkyldiketide-CoA synthase W332Q mutant from Evodia rutaecarpa
Method: X-RAY DIFFRACTION / Resolution: 1.799 Å

PDB-5wx7:
Alkyldiketide-CoA synthase W332G mutant from Evodia rutaecarpa
Method: X-RAY DIFFRACTION / Resolution: 1.904 Å

Chemicals

ChemComp-COA:
COENZYME A

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • tetradium ruticarpum (plant)
KeywordsTRANSFERASE / polyketidesynthase / polyketide synthase

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